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The studies found that aerobic exercise, resistance training, and swimming increased PPARγ mRNA expression levels in different tissues and organs, including skeletal muscles, liver, colon, and aorta. Exercise was also shown to upregulate PPARγ activity and prevent colonic inflammation in high-fat diet-induced obesity.Some of the specific findings included:* Aerobic exercise significantly upregulated PPARγ mRNA expression levels in all tissues and skeletal muscles.* Resistance training increased PPARγ mRNA expression levels in the colon and aorta.* Swimming reduced atherosclerotic lesion size and increased PPARγ expression in the aorta.* Exercise prevented colonic inflammation in high-fat diet-induced obesity by up-regulating PPARγ activity.Overall, the studies suggest that exercise can improve PPARγ function and may have beneficial effects on glucose metabolism, cardiovascular health, and overall well-being.
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