Cocaine can make a person feel full of energy but also restless, scared, or angry. Heroin causes a rush of good feelings initially, followed by sleepiness and slowed heart rate. Methamphetamine causes an initial rush of good feelings, then users may feel edgy, excited, angry, or afraid. Prescription pain medicines like OxyContin and Vicodin can cause addiction, sleepiness, and itching. Other drugs include ecstasy, K2/Spice, LSD, PCP, inhalants, and club drugs like bath salts. Substance abuse can interfere with daily life, lead to physical and mental health problems, and increase the risk of overdose or death.