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Here is a list of supporting information that can be found in the online version of the article:1. Supplemental Figure 1: This figure shows the distribution of B cell subsets in the peripheral blood of patients with periodontitis and healthy controls.2. Supplemental Table 1: This table presents the demographic and clinical characteristics of the study participants.3. Supplemental Table 2: This table shows the mean cytokine levels in the peripheral blood of patients with periodontitis and healthy controls.4. Supplemental Figure 2: This figure demonstrates the expression of TLR2 and TLR4 on B cells from patients with periodontitis and healthy controls.5. Supplemental Table 3: This table lists the primer sequences used for PCR analysis of TLR2 and TLR4 in B cells.6. Supplemental Figure 3: This figure shows the results of flow cytometry analysis of B cells from patients with periodontitis and healthy controls.7. Supplemental Table 4: This table presents the statistical analyses used to compare the cytokine levels in the peripheral blood of patients with periodontitis and healthy controls.8. Supplemental Figure 4: This figure demonstrates the effects of TLR2 and TLR4 ligands on B cell activation and cytokine production.9. Supplemental Table 5: This table lists the references cited in the article.To access these supporting information, please refer to the online version of the article at <https://doi.org/10.1002/JPER.22-0438>.