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Stress, anxiety, and depression can exacerbate pain, and addressing one area can positively impact the others. The interconnectedness among these areas is evident in the activation of the sympathetic nervous system under stress, which can lead to symptoms of anxiety or fear. Long-term negative stress experience can also manifest as depression symptoms. Behavioral interventions aimed at one area can have a cascading effect on the others. For instance, improving sleep quality can alleviate both pain and stress. Another example is Acceptance and Commitment Therapy (ACT), which focuses on changing the way individuals approach their emotions and thoughts while practicing mindfulness and value-based actions. This therapy has been shown to be effective in managing pain, which can also reduce stress discomfort.